Tetanus/Diphtheria/Pertussis booster vaccine

Study background

Tetanus/Diphtheria/Pertussis (TDAP) vaccine is a vaccine targeting these bacterial infections which can have devastating outcomes on unprotected people. There has recently been an increased incidence of Pertussis (whooping cough), especially in adolescents and adults in vaccinated countries. This may be due to the current vaccines not providing enough immunity.

This voluntary research study is being conducted to see if a new investigational TDAP vaccine can better protect people against these infections. If you agree to take part, you will be assigned randomly to receive either the study vaccine or an approved comparator, Boostrix.

Study Details

The study would require you to come to the clinic 4 times over 3-4 months and you may engage in 1 follow-up phone call. Visits will range between 15 mins to an hour each time you come in. Over the course of the study, we will check your medical history, draw blood, and vaccinate you. You will also need to complete a participant diary for 7 days following the vaccination.

You will be reimbursed for your time and involvement in the research study. 

Eligibility criteria

  • Aged between 18 to 22 years
  • Documentation of 2 or more prior acellular pertussis vaccinations
  • Have not had a TDAP vaccination within 3 years
  • Ineligible if there is a history of autoimmune conditions