Vaccine for elevated cholesterol

Study background

Elevated Cholesterol is a medical condition in which there are high amounts of cholesterol in your blood. Elevated Cholesterol can limit blood flow which can increase the risk of a heart attack or stroke. There are 2 main types of Cholesterol: Low-Density Lipoprotein (LDL) also known as bad cholesterol, and High-Density Lipoprotein (HDL) also known as good cholesterol.

This research study is investigating a vaccine which aims to lower LDL cholesterol. This could be useful for people with elevated LDL that is poorly controlled by statins alone. Participants will be assigned randomly to receive either the study vaccine or a placebo.

Study Details

The study would require you to come to the clinic approximately 14 times over an 8-month period. Visits will range between 15 minutes to 6 hours each time you come in. Over the course of the study, we will check your medical history, take your blood and administer the vaccine. The vaccine will be administered 4 times over the course of the study. You will also need to complete a diary over the course of the study.

You will be reimbursed for your time and expenses related to the research study.

Eligibility criteria

  • Aged 18 to 75 years
  • Has elevated LDL levels (2.59 mmol/L – 4.89mmol/L)
  • Is not currently taking any lipid-lowering prescription medications
  • Relatively healthy

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